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Mai-Anh T. Vu
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[email protected]
Rajen Kilachand Center for Integrated Life Sciences & Engineering
Boston University
610 Commonwealth Avenue
Boston, MA 02215
Rajen Kilachand Center for Integrated Life Sciences & Engineering
Boston University
610 Commonwealth Avenue
Boston, MA 02215
Education & TRAINING
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2018-
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Boston University
NIH Brain Initiative Postdoctoral Fellow Mentor: Mark Howe, PhD |
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2018
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Duke University
PhD, Neurobiology Certificate in Cognitive Neuroscience Certificate in College Teaching Mentors: R. Alison Adcock, MD, PhD & Kafui Dzirasa, MD, PhD |
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2009
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Yale University
BA, Cognitive Science |
AWARDS, fellowships, & funding
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2017-2018
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Duke University Katherine Goodman Stern Fellowship
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2017
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Duke University Graduate School Conference Travel Award
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2015-2016
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Duke Scholar in Molecular Medicine
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2016
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Duke University Graduate School Conference Travel Award (x2)
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2013-2018
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National Science Foundation Graduate Research Fellowship
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2012-2016
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Duke University James B. Duke Fellowship
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2012
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Duke University Chancellor's Fellowship
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2009
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Yale University Asian American Cultural Center Leadership Award
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2008
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Yale University Asian American Cultural Center Appreciation Award
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2005
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National Merit Scholar
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research APPOINTMENTS
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2018-present
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Howe Lab
Boston University PI: Mark Howe, PhD NIH Postdoctoral Fellow, Research Scientist |
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2013-2018
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Lab for Psychiatric Neuroengineering
Duke University PI: Kafui Dzirasa, MD, PHD PhD Student |
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2012-2018
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Motivated Memory Lab
Duke University PI: R. Alison Adcock, MD, PhD PhD Student |
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2009-2012
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Psychiatry Neuroimaging Laboratory
Harvard Medical School, Brigham & Women’s Hospital Director: Martha E. Shenton, PhD Mentors: Martha E. Shenton, PhD, Chandlee C. Dickey, MD Head Research Assistant, Research Assistant |
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2007
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Schacter Memory Lab
Harvard University PI: Daniel L. Schacter, PhD Mentor: Donna Rose Addis, PhD Undergraduate Summer Research Assistant |
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2006-2008
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Arnsten Lab
Yale University PI: Amy F. T. Arnsten, PhD Mentors: Amy F. T. Arnsten, PhD, Avis Brennan Hains, PhD Undergraduate Research Assistant |
publications
PREPRINTS
1. Brown EH, Zi Y, Vu MT, Bouabid S, Lindsey J, Godfrey-Nwachukwu C, Attarwala A, Litwin-Kumar A, DePasquale B, Howe MW. Spatially organized striatal neuromodulator release encodes trajectory errors. bioRxiv; 2024.
2. Bouabid S, Zhang L, Vu MT, Tang K, Graham BM, Noggle CA, Howe MW. Spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian cues and actions. bioRxiv; 2024.
PEER-REVIEWED PUBLICATIONS
3. Vu MT, Brown EH, Wen MJ, Noggle CA, Zhang Z, Monk KJ, Bouabid S, Mroz L, Graham BM, Zhuo Y, Li Y, Otchy TM, Tian L, Davison IG, Boas DA, Howe MW. Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior. Neuron 2024; 112(6):909-923.e9.
4. Poh J-H, Vu MT, Stanek JK, Hsiung A, Egner T, Adcock RA. Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation. Nature Communications 2022; 13: 6729.
5. Chiew KS, Hashemi J, Gans LK, Lerebours L, Clement NJ, Vu MT, Sapiro G, Heller NE, Adcock RA. Motivational valence alters memory formation without altering exploration of a real-life spatial environment. PLoS One 2018; 13(3): e0193506.
6. Hultman R*, Ulrich K*, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L+, Dzirasa K+. Brain-wide electrical spatiotemporal dynamics encode depression vulnerability. Cell 2018; 173(1):166-180.e14. *,+denote equally contributing authors
7. Vu MT, Adali T, Ba D, Buzsáki G, Carlson D, Heller K, Liston C, Rudin C, Sohal VS, Widge A, Mayberg H, Sapiro G, Dzirasa K. A Shared Vision for Machine Learning in Neuroscience. The Journal of Neuroscience 2018; 38(7):1601-1607.
8. Carlson D*, David LK*, Gallagher NM*, Vu MT*, Shirley M, Hultman R, Wang J, Burrus C, McClung CA, Kumar S, Carin L, Mague SD, Dzirasa K. Dynamically-timed stimulation of corticolimbic circuitry activates a stress-compensatory pathway. Biological Psychiatry 2017; 82(12):904-913. *denotes equally contributing authors
9. Schaich Borg J*, Vu M*, Badea C, Badea A, Johnson GA, Dzirasa K. Localization of metal electrodes in the intact rat brain using registration of 3-D micro-computed tomography images to a magnetic resonance histology atlas. eNeuro 2015; 2(4). *denotes equally contributing authors
10. Kikinis K, Fitzimmons J, Dunn C, Vu MA, Makris N, Bouix S, Goldstein JM, Mesholam-Gately RI, Petryshen T, Del Re EC, Wojcik J, Seidman LJ, Kubicki M. Anterior commissural white matter fiber abnormalities in first-episode psychosis: a tractography study. Schizophrenia Bulletin 2015; 162(1-3):29-34.
11. Hütlova J, Kikinis Z, Kerkovsky M, Bouix S, Vu MA, Makris N, Shenton M, Kasparek T. Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing. The Cerebellum 2014: 1-10.
12. Vu MT, Thermenos HW, Terry DP, Wolfe DJ, Voglmaier MM, Niznikiewicz MA, McCarley RW, Seidman LJ, Dickey CC. Functional differences during working memory in schizotypal personality disorder: fMRI activation and deactivation differences. Schizophrenia Research 2013; 151(1):113-123.
13. Addis DR, Giovanello KS, Vu MT, Schacter DL. Age-related changes in prefrontal and hippocampal contributions to relational encoding. Neuroimage 2014; 84:19-26.
14. Clemm von Hohenberg C, Pasternak O, Kubicki M, Ballinger T, Vu M, Swisher T, Green K, Giwerc K, Dahlben B, Goldstein JM, Woo TW, Petryshen TL, Mesholam-Gately RI, Woodberry KA, Thermenos HW, Mulert C, McCarley RW, Seidman LJ, Shenton ME. White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study. Schizophrenia Bulletin 2014; 40(4):895-903.
15. Dickey CC, Vu M-A T, Voglmaier MM, Niznikiewicz MA, McCarley RW, Panych LP. Prosodic abnormalities in schizotypal personality disorder. Schizophrenia Research 2012; 142(1-3):20-30.
16. Shenton ME, Hamoda H, Schneiderman J, Bouix S, Pasternak O, Rathi Y, Vu M-A, Purohit MP, Helmer K, Koerte I, Lin AP, Westin C-F, Kikinis R, Kubicki M, Stern RA, Zafonte R. A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging and Behavior 2012; 6:137-192.
17. Addis DR, Pan L, Vu MA, Laiser N, Schacter DL. Constructive episodic simulation of the future and the past: distinct subsystems of a core brain network mediate imagining and remembering. Neuropsychologia 2009; 47(11):2222-38.
18. Hains AB, Vu MA, Maciejewski PK, van Dyck CH, Gottron M, Arnsten AF. Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress. Proceedings of the National Academy of Science USA 2009; 106(42):17957-62.
19. Brennan AR, Dolinsky B, Vu MA, Stanley M, Yeckel MF, Arnsten AF. Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory. Learning & Memory 2008;15(3):93-6.
1. Brown EH, Zi Y, Vu MT, Bouabid S, Lindsey J, Godfrey-Nwachukwu C, Attarwala A, Litwin-Kumar A, DePasquale B, Howe MW. Spatially organized striatal neuromodulator release encodes trajectory errors. bioRxiv; 2024.
2. Bouabid S, Zhang L, Vu MT, Tang K, Graham BM, Noggle CA, Howe MW. Spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian cues and actions. bioRxiv; 2024.
PEER-REVIEWED PUBLICATIONS
3. Vu MT, Brown EH, Wen MJ, Noggle CA, Zhang Z, Monk KJ, Bouabid S, Mroz L, Graham BM, Zhuo Y, Li Y, Otchy TM, Tian L, Davison IG, Boas DA, Howe MW. Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior. Neuron 2024; 112(6):909-923.e9.
4. Poh J-H, Vu MT, Stanek JK, Hsiung A, Egner T, Adcock RA. Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation. Nature Communications 2022; 13: 6729.
5. Chiew KS, Hashemi J, Gans LK, Lerebours L, Clement NJ, Vu MT, Sapiro G, Heller NE, Adcock RA. Motivational valence alters memory formation without altering exploration of a real-life spatial environment. PLoS One 2018; 13(3): e0193506.
6. Hultman R*, Ulrich K*, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L+, Dzirasa K+. Brain-wide electrical spatiotemporal dynamics encode depression vulnerability. Cell 2018; 173(1):166-180.e14. *,+denote equally contributing authors
7. Vu MT, Adali T, Ba D, Buzsáki G, Carlson D, Heller K, Liston C, Rudin C, Sohal VS, Widge A, Mayberg H, Sapiro G, Dzirasa K. A Shared Vision for Machine Learning in Neuroscience. The Journal of Neuroscience 2018; 38(7):1601-1607.
8. Carlson D*, David LK*, Gallagher NM*, Vu MT*, Shirley M, Hultman R, Wang J, Burrus C, McClung CA, Kumar S, Carin L, Mague SD, Dzirasa K. Dynamically-timed stimulation of corticolimbic circuitry activates a stress-compensatory pathway. Biological Psychiatry 2017; 82(12):904-913. *denotes equally contributing authors
9. Schaich Borg J*, Vu M*, Badea C, Badea A, Johnson GA, Dzirasa K. Localization of metal electrodes in the intact rat brain using registration of 3-D micro-computed tomography images to a magnetic resonance histology atlas. eNeuro 2015; 2(4). *denotes equally contributing authors
10. Kikinis K, Fitzimmons J, Dunn C, Vu MA, Makris N, Bouix S, Goldstein JM, Mesholam-Gately RI, Petryshen T, Del Re EC, Wojcik J, Seidman LJ, Kubicki M. Anterior commissural white matter fiber abnormalities in first-episode psychosis: a tractography study. Schizophrenia Bulletin 2015; 162(1-3):29-34.
11. Hütlova J, Kikinis Z, Kerkovsky M, Bouix S, Vu MA, Makris N, Shenton M, Kasparek T. Abnormalities in Myelination of the Superior Cerebellar Peduncle in Patients with Schizophrenia and Deficits in Movement Sequencing. The Cerebellum 2014: 1-10.
12. Vu MT, Thermenos HW, Terry DP, Wolfe DJ, Voglmaier MM, Niznikiewicz MA, McCarley RW, Seidman LJ, Dickey CC. Functional differences during working memory in schizotypal personality disorder: fMRI activation and deactivation differences. Schizophrenia Research 2013; 151(1):113-123.
13. Addis DR, Giovanello KS, Vu MT, Schacter DL. Age-related changes in prefrontal and hippocampal contributions to relational encoding. Neuroimage 2014; 84:19-26.
14. Clemm von Hohenberg C, Pasternak O, Kubicki M, Ballinger T, Vu M, Swisher T, Green K, Giwerc K, Dahlben B, Goldstein JM, Woo TW, Petryshen TL, Mesholam-Gately RI, Woodberry KA, Thermenos HW, Mulert C, McCarley RW, Seidman LJ, Shenton ME. White Matter Microstructure in Individuals at Clinical High Risk of Psychosis: A Whole-Brain Diffusion Tensor Imaging Study. Schizophrenia Bulletin 2014; 40(4):895-903.
15. Dickey CC, Vu M-A T, Voglmaier MM, Niznikiewicz MA, McCarley RW, Panych LP. Prosodic abnormalities in schizotypal personality disorder. Schizophrenia Research 2012; 142(1-3):20-30.
16. Shenton ME, Hamoda H, Schneiderman J, Bouix S, Pasternak O, Rathi Y, Vu M-A, Purohit MP, Helmer K, Koerte I, Lin AP, Westin C-F, Kikinis R, Kubicki M, Stern RA, Zafonte R. A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging and Behavior 2012; 6:137-192.
17. Addis DR, Pan L, Vu MA, Laiser N, Schacter DL. Constructive episodic simulation of the future and the past: distinct subsystems of a core brain network mediate imagining and remembering. Neuropsychologia 2009; 47(11):2222-38.
18. Hains AB, Vu MA, Maciejewski PK, van Dyck CH, Gottron M, Arnsten AF. Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress. Proceedings of the National Academy of Science USA 2009; 106(42):17957-62.
19. Brennan AR, Dolinsky B, Vu MA, Stanley M, Yeckel MF, Arnsten AF. Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory. Learning & Memory 2008;15(3):93-6.
RECENT TALKS AND PRESENTED ABSTRACTS
2024
1. Vu, MT. Using multifiber photometry to investigate dopamine and acetylcholine dynamics across the striatum during behavior in health and in a Parkinson’s disease model. Meeting talk, Aligning Science Across Parkinson’s (ASAP) Tech 2b Meeting: PD Modeling - Rodent and Fly Models, Virtual, September 2024.
2. Vu MT, Bouabid S, Zhang L, Joshi A, Mroz L, Howe MW. Spatiotemporal Organization of Striatum-Wide Dopamine and Acetylcholine Signaling During Locomotion in Healthy and Parkinsonian States Revealed by Optical Microfiber Arrays. Poster presented at the Aligning Science Across Parkinson’s (ASAP) annual Celebration of Scientific Achievement, Virtual, May 2024.
3. Vu MT. Striatal spatiotemporal heterogeneity in learning-related changes in dopamine signals to Pavlovian cues. Conference talk, Boston University Center for Systems Neuroscience Neuromodulation Symposium “Neurotransmission is lit!: Monitoring acetylcholine and monoamine dynamics during behavior”, Boston, MA, USA, May 2024.
4. Vu MT. Multi-fiber photometry reveals dynamic changes in the coordination of striatum-wide dopamine and acetylcholine release. Invited talk, Brandeis University Computational Neuroscience Journal Club. Waltham, MA, USA, Apr 2024.
5. Vu MT. Multi-fiber photometry reveals dynamic changes in the coordination of striatum-wide dopamine release. Panel talk, Winter Conference on Brain Research. Breckenridge, CO, USA, Jan 2024.
2023
1. Vu MT, Wen MJ, Brown EH, Zhang Z, Mroz L, Graham BM, Bouabid S, Otchy TM, Boas DA, Howe MW. Multi-fiber photometry reveals functionally distinct spatiotemporal topography of striatum-wide dopamine release. Poster presented at the Society for Neuroscience Annual Meeting, Washington, D.C., USA, Nov 2023.
2. Vu MT, Brown EH, Wen MJ, Zhang Z, Mroz L, Otchy TM, Boas DA, Howe MW. Striatum-wide monitoring of DA release reveals contributions from distinct action, sensory, and reward-related spatiotemporal dynamics. Poster presented at the XIV Meeting of the International Basal Ganglia Society. Stockholm, Sweden, Jun 2023.
3. Vu MT. Spatiotemporal patterns of striatal dopamine release. Meeting Talk, Aligning Science Across Parkinson's Collaboration Team Cragg Annual Meeting. Stockholm, Sweden, Jun 2023.
4. Vu MT, Wen MJ, Brown EH, Mroz L, Otchy TM, Boas DA, Howe MW. Specific spatiotemporal dynamics of striatum-wide DA release at acceleration and deceleration events. Poster presented at the Aligning Science Across Parkinson's Team Cragg Poster Day. Virtual, Mar 2023.
5. Vu MT, Wen MJ, Brown EH, Mroz L, Otchy TM, Boas DA, Howe MW. Spatially and temporally selective dynamics of striatum-wide dopamine release to conditioned and unconditioned stimuli and rewards. Poster presented at the Winter Conference on Brain Research. Snowbird, UT, USA, Jan 2023.
1. Vu, MT. Using multifiber photometry to investigate dopamine and acetylcholine dynamics across the striatum during behavior in health and in a Parkinson’s disease model. Meeting talk, Aligning Science Across Parkinson’s (ASAP) Tech 2b Meeting: PD Modeling - Rodent and Fly Models, Virtual, September 2024.
2. Vu MT, Bouabid S, Zhang L, Joshi A, Mroz L, Howe MW. Spatiotemporal Organization of Striatum-Wide Dopamine and Acetylcholine Signaling During Locomotion in Healthy and Parkinsonian States Revealed by Optical Microfiber Arrays. Poster presented at the Aligning Science Across Parkinson’s (ASAP) annual Celebration of Scientific Achievement, Virtual, May 2024.
3. Vu MT. Striatal spatiotemporal heterogeneity in learning-related changes in dopamine signals to Pavlovian cues. Conference talk, Boston University Center for Systems Neuroscience Neuromodulation Symposium “Neurotransmission is lit!: Monitoring acetylcholine and monoamine dynamics during behavior”, Boston, MA, USA, May 2024.
4. Vu MT. Multi-fiber photometry reveals dynamic changes in the coordination of striatum-wide dopamine and acetylcholine release. Invited talk, Brandeis University Computational Neuroscience Journal Club. Waltham, MA, USA, Apr 2024.
5. Vu MT. Multi-fiber photometry reveals dynamic changes in the coordination of striatum-wide dopamine release. Panel talk, Winter Conference on Brain Research. Breckenridge, CO, USA, Jan 2024.
2023
1. Vu MT, Wen MJ, Brown EH, Zhang Z, Mroz L, Graham BM, Bouabid S, Otchy TM, Boas DA, Howe MW. Multi-fiber photometry reveals functionally distinct spatiotemporal topography of striatum-wide dopamine release. Poster presented at the Society for Neuroscience Annual Meeting, Washington, D.C., USA, Nov 2023.
2. Vu MT, Brown EH, Wen MJ, Zhang Z, Mroz L, Otchy TM, Boas DA, Howe MW. Striatum-wide monitoring of DA release reveals contributions from distinct action, sensory, and reward-related spatiotemporal dynamics. Poster presented at the XIV Meeting of the International Basal Ganglia Society. Stockholm, Sweden, Jun 2023.
3. Vu MT. Spatiotemporal patterns of striatal dopamine release. Meeting Talk, Aligning Science Across Parkinson's Collaboration Team Cragg Annual Meeting. Stockholm, Sweden, Jun 2023.
4. Vu MT, Wen MJ, Brown EH, Mroz L, Otchy TM, Boas DA, Howe MW. Specific spatiotemporal dynamics of striatum-wide DA release at acceleration and deceleration events. Poster presented at the Aligning Science Across Parkinson's Team Cragg Poster Day. Virtual, Mar 2023.
5. Vu MT, Wen MJ, Brown EH, Mroz L, Otchy TM, Boas DA, Howe MW. Spatially and temporally selective dynamics of striatum-wide dopamine release to conditioned and unconditioned stimuli and rewards. Poster presented at the Winter Conference on Brain Research. Snowbird, UT, USA, Jan 2023.
teaching
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2020-2023 Spring
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Guest Lecturer, Boston University
PS 504: Contemporary Trends in Psychology: Neurobiology of Motivation and Movement Control Instructor: Mark Howe, Ph.D. Guest lecture: “Studies on Human Motivation” |
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2022 Spring
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Guest Lecturer, Purdue University
Psy 20000: Introduction to Cognitive Psychology Instructor: Nadia Brashier, Ph.D. Guest lecture: “Learning from Experience: From Pavlov’s Dogs to Computers Solving Problems” |
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2015 Fall
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Teaching Assistant, Duke University
Neurosci 211: Brain & Behavior: Translating Neuroscience (~50 undergraduates) Instructors: Kafui Dzirasa, M.D., Ph.D.; Rainbo Hultman, Ph.D.; Stephen Mague, Ph.D. Instructor for two weekly discussion sections, assisted in course design, led additional review sessions, created and graded assignments/assessments Guest lecture: “Social Processes” |
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2015 Spring
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Teaching Assistant, Duke University
Neurosci 223: Cellular & Molecular Neurobiology (~100 undergraduates) Instructors: Nina Sherwood, Ph.D. & Pelin Volkan, Ph.D. Instructor for weekly discussion section, led additional review sessions, graded assignments, and created problem sets for undergraduates |
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2010-2012
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Mentor, Tutor, Classroom Assistant
Boston Partners in Education Fenway High School |
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2008-2009
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Assistant Director, ESL Teacher, Camp Counselor
NACEL American Village (France) |
service
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2022
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Planning Committee, The Brain Initiative Meeting 2022: Open Science, New Tools
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2017-2018
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Student Representative, Duke Institute for Brain Sciences Strategic Planning Committee
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2017-2018
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Student Representative, Neurobiology Diversity & Inclusion Committee
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2016-2017
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Student Representative, Neurobiology Seminar Committee
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2015-2016
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Co-Chair, Duke Institute for Brain Sciences Graduate Consortium
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2013-2014
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Coordinator, Center for Cognitive Neuroscience Journal Club
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2013,2014
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Student Coordinator, Cognitive Neuroscience Admitting Program Recruitment
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2013,2014
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Presenter and Activity Leader, Brain Awareness Week
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mentorship
I have had so many great mentors along the way who helped me get to where and who I am, and will forever pay that forward, via both formal and informal mentoring. Within the lab, I have formally mentored 14 undergraduate students (3 did honors thesis projects with me, 6 continued in the lab as lab technicians, and 2 continued in the lab as graduate students), 2 lab technicians, and 3 high school students.